BUY 5-Amino-1MQ 50mg (60 Capsules)

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5-amino-1MQ is a small molecule that blocks the activity of the enzyme called nicotinamide N-methyltransferase (NNMT). NNMT is a very important component in metabolism and energy and is predominantly active in fat tissue. By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1).

SIRT1 is also known as the “longevity gene” because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer. Research in mice given 5-amino-1MQ showed a 7% reduction in body mass over 10 days without any changes in food intake, compared to controls. Research has shown that decreasing NNMT may help shrink fat cells and reduce the size of fat deposits

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5-Amino-1 MQ Overview

Buy Peptides canada 5-amino-1MQ (5-amino-1methylquinolinium) an analogue of methylquinolinium, is a short peptide inhibitor of cytosolic nicotinamide N- methyltransferase (NNMT). The NNMT enzyme has been linked to both obesity and type 2 betes and is known to play a role in energy meostasis within the cell. Inhibiting NNMT |ds to significant weight loss, decreased fat iss and fat cell (adipocyte) size, and lower sma cholesterol and glucose levels. 5-amino- rvQ and other methylquinolinium derivatives are under active investigation as potential treatments for obesity and diabetes. It also appears that inhibition of NNMT can activate stem cells and improve regenerative capacity in skeletal muscle.

5-Amino-1 MQ Research

Obesity

Nicotinamide N-methyltransferase is a cytosolic enzyme found in many cells throughout the body, but is most abundant in liver and fat cells. Pesearch in mice shows that high levels of MT are associate with decrease levels of sugar transporter GLUT4.

5-Amino-1MQ and Muscle Function

The impact of 5-amino-1 MQ on skeletal muscle is multifaceted. Much like in adipose tissue, the presence of 5-amino-1 MQ in muscle promotes production of the GLUT4 receptor and psts the inefficiency of metabolism leading to reased energy burn. Recent research in mice, wever, suggests that inhibiting NNMT in any y,including with 5-amino-1Mo. may actully boost muscle repair by stimulating stem cells.

A Possible Role for 5-Amino-1MQ in Cognition

NAD+ is a critical compound in brain energy homeostasis. Depletion of NAD-+ has been Jlinķed to a number of cognitive conditions, but is pwn to impact communication at the synaptic ction of neurons and at the neuromuscular ction where nerves connect to muscle tissue. search in mice suggests that decreases in [D-+ levels can reduce synaptic transmission, impair muscle function, and impact overall cognitive function [1 0]. Though 5-amino-1 MQ has not been specifically test in this setting, there is good reason to believe that the compound will have the same effect on NAD+ levels in the brain as it has elsewhere.

NNMT and Cancer

It remains to be seeing whether 5-amino-1MQ, by reducing NNMT function, will have any effect on the various cancers mention.

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